Peptides 101

Episode 185: Peptides: the wellness buzzword everyone's talking about. Modi and Leo welcome back Dr. Andrew Kibert to explain what peptides actually are, whether they can reduce "food noise," help with recovery, and yes - even make you more tan.

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Transcript

Welcome Back To Peptides

SPEAKER_01 0:00

And welcome to and here's Modi. We are in the studio with Leo Vega, my partner, husband, and uh everything else in my life. And our doctor, Dr. Andrew Kibbert, uh, who's been on the episode before. Uh, it was a big success. The episode you were on. People loved you, uh, shared you the clips and your knowledge, and I believe it even brought you some patience. Okay, and now we're back here, and we are uh we're gonna debunk. Is that no? I don't know why. Maybe we're gonna discuss. I just wanted to say debunk. Yeah, it's a good word. Yeah, that's great.

SPEAKER_02 0:40

Yeah. Peptides. Peptides, the talk of the town. It is. Yes, Dr. Kibbert was with us for episode 116, which was back in June or July of 2024, so it's been a minute. But you have not exited our lives. You have been you have been with us in uh different forms uh since then. But everyone's talking about peptides, and I feel like we should have you on. We should discuss what's going on, what the kids are up to.

SPEAKER_01 1:11

Well, I'm happy to be back.

SPEAKER_02 1:12

Thanks for inviting me.

SPEAKER_01 1:13

Thanks for coming back, and uh, that's it. Let's pep, let's pep it out. Let's let's give us a pep talk. Pep talk on peptide. Yes.

What A Peptide Actually Is

SPEAKER_00 1:23

What the hell's a peptide, Andrew? You know, that's a that's a great question. I think that's thank you. It's a good starting point. All all a peptide is is a sequence of amino acids. But to break that down even more, really what a peptide is is a small protein. Proteins, large structures, peptides are small proteins, and amino acids are the individual building blocks of those peptides. Okay. That's that's the essential of what you need to know in terms of like what is a peptide. It's a small protein. If you if you know that, you're ahead of 90% of the population. So that's it. Protein pro peptide protein. Yeah.

SPEAKER_01 1:59

And if you want small protein. Small protein. There, now you got it. Okay. Peptide is a small protein. Okay. That you told us our body makes. That's right.

SPEAKER_00 2:09

Anyway. That's correct. Right. From from uh from uh conception, one might say. You know, the the protein uh processing is is underway. Ultimately, your cells, your DNA is used to generate proteins. So right now, my body, your body, Leo's body, our genetic machinery, our DNA, is being turned into proteins. That's why our DNA exists. So to think that proteins or peptides are bad, it's like, well, you don't understand how DNA works.

SPEAKER_01 2:40

Okay. So how the hell are we now in the world that everybody's talking about it? No one was talking a few years ago, nobody was talking about, and I mean few two years ago, nobody was talking about it. It's been very fast. How come all of a sudden the protein of our bodies is the main conversation?

SPEAKER_00 2:55

I would say I think I think two reasons. I think one, there is a growing awareness of the importance of not only maintaining and preserving physical function and mental function, but actually enhancing. So I think there's a growing awareness where people are seeking solutions to improve some aspect of

Why Peptides Suddenly Took Off

SPEAKER_00 3:10

themselves. So I think peptides offer a possible route to that. And I think what thrust peptides into the spotlight was certainly the GLP one drugs.

SPEAKER_02 3:18

Let's talk about that. Yeah, because there's been even, again, even in the last one, two years within the GLP one you gotta keep up.

SPEAKER_01 3:25

What whatever there's people who don't know what a GLP one drug is, just so let's just make sure that's true. GLP one is is everybody's in Osempic. That's the Ozempic world. Correct. The ones that are help you curb your appetite and feel satiated. Feel satiated.

SPEAKER_02 3:43

And that has to do with your insulin uh response, correct?

SPEAKER_00 3:46

Yes. And I would say to give, since we're asking a technical question, we'll give more of a technical answer. I think you can hold in your mind there are two main ways in which the GLP ones work. One, they promote satiety, feeling of fullness, so that you consume less. Yes. And I'm choosing my words here carefully, consume less. Okay. That could apply to many different forms of consumption. Could be food, could be beverage, could be alcohol, could be other things. And they also improve metabolism by increasing insulin sensitivity. So you have two different ways. You're kind of speeding up metabolism, reducing caloric intake, which of course is how you translate into a reduction in blood sugar, and of course, body weight.

SPEAKER_02 4:22

Yeah. So we started with um Ozempic, which is semaglutide. Correct. That was kind of everyone's initial introduction, at least from pop culture and being out and about in the world from my point of view. And then from there we got to trisepatide, which is also known as like w uh wiggle uh Manjaro.

SPEAKER_00 4:43

Manjaro zep bounds, correct.

SPEAKER_02 4:44

Yeah. So how does GL how do how does semaglutide, how is that different from then trisepatide?

SPEAKER_00 4:50

Great. So I think to the the first point here is that GLP1 is a

GLP-1 Basics For Appetite Control

SPEAKER_00 4:55

naturally occurring hormone. Okay. It's an endogenous hormone. It's a hormone that also is a peptide because it is made up of amino acids, right? That's the definition of a peptide, small protein. The subsequent generations of GLP1 products are modified synthetic forms of that naturally occurring peptide GLP1. Okay. So when Ozempic products came out, these are semaglutide products, the big innovation was extending the half-life of the compound. Endogenous naturally produced GLP1, gets degraded by the body by enzymes within minutes. Really? So you couldn't do once weekly dosing. So the real innovation with Ozempic with semaglutide was a modification of the molecular sequence so that it just stays for in your body longer, so you don't have to take it as often. So that's one of the big innovations with Ozempic. Once weekly dosing has a long half-life, about seven days or so, compared to the endogenous naturally occurring version, which is really like minutes. Okay. And then from there, trisepatide. Correct. So then you had trzepatide come out, which had activity not only the GLP1 receptor, okay, but also the GIP receptor. And then, of course, in the pipeline with Eli Lilly in phase three clinical trials right now, you have retatrutite or retatritite, depending on which pronunciation bandwagon you you are on. Retta.

SPEAKER_02 6:16

The bodybuilders are just calling it REDTA. That's right.

SPEAKER_00 6:19

Semater's REDA.

SPEAKER_02 6:20

Yeah.

SPEAKER_00 6:20

Okay. Yeah. Um, this has activity not only the GLP1 and also GIP, but also the glucagon receptor. So you're seeing a trend here that subsequent generations of products are more nuanced to have activity at multiple receptors with certain goals in mind.

SPEAKER_02 6:35

But you said Retta, you said REDA is in clinical trial trials. That's correct. But people are using it all over the place. I'm getting ads for it on my Instagram, like for telehealth things to do a quick appointment with the doctor and then you get it delivered to your house already. So even though it's kind of explain, yeah, sorry.

SPEAKER_01 6:51

So even though it's not approved, you can still get it.

SPEAKER_00 6:55

You're you're asking a very high-level nuanced question that I don't know if we're gonna get it this question we've had so far on the episode.

SPEAKER_02 7:04

If

Semaglutide Vs Tirzepatide Vs Retatrutide

SPEAKER_02 7:05

I can buy it with my face on Apple Pay, yeah, if I can double-click the side of my phone and have it show up to my house, yeah. What's going on with that?

SPEAKER_00 7:12

Well, you are you asking for the official or the unofficial answer? You can give one. You feel comfortable with it. You have time? Yeah, we have plenty of time. Um, so officially, okay, Reddit true tide cannot be compounded. Okay. Officially, according to the FDA. Unofficially, there are channels potentially to procure the compound. This is very gray market. It's called gray market. Uh, but reditrutide is not approved yet. Um, I will also point out that coming up next month in July 2026, the FDA will hold a board review examining, or I should say, re-examining about 12 peptides, potentially reclassifying those peptides. Um, it's constantly in flux. So part of my 12, what are those 12 on the horizon? Uh BPC 157, uh, thymus and beta, um uh what else is on there? MOT C, KPV, uh anything interesting of those though? Oh, for sure. There are lots of lots of interesting uh compounds on that on that list. But I guess the point here, I think for people listening, is the FDA landscape of what is permissible, what is compoundable, what you can manufacture, it's constantly in flux. And so part of my job is kind of keeping it.

SPEAKER_02 8:24

Yeah. As a concierge doctor, how do you keep in touch with what people are coming to you? Well, I saw on the internet the kids are doing this versus what you've guide them through.

SPEAKER_00 8:32

FDA press release, speaking with my pharmacist, understanding the landscape, you know, experimenting with your patients. Uh uh. Healthy supervised uh experimentation, sure.

SPEAKER_01 8:43

Yeah, and we we love being those. We love being those. We just had um we we obviously we have our stan, our uh horse, our one and only.

SPEAKER_02 8:53

The one and only our mutual trainer, he trains you too. That's right.

SPEAKER_01 8:56

Yeah, who has the 13, sometimes 13 to 14 clients a day. He's there from 7 a.m. to smiling and not happy and not peppy. And now he recently discovered what was it? Uh S133. I think you're thinking SS31. S31. So I got it right. Uh and and he's like, this is it. I uh I didn't sleep, but I have energy.

SPEAKER_00 9:29

Yeah, that's a lot. That sounds about right. Yeah. Um, you know, SS31 uh belongs to a a different class of peptides outside of the GOP ones, all of this. Right. They belong to a class called mitochondrial peptides. Mitochondrial peptides are a little bit of the new new. Okay.

SPEAKER_02 9:47

Excuse me, I have something to say. Mitochondria is the powerhouse of the cell. A plus, someone took AP bio. Isn't that I thought I thought it was a Disney movie? It's one of those things just floating around in my brain. Like just that'll be in there forever.

SPEAKER_00 9:59

Mitochondria is the powerhouse of the cell. It looks like a little mouth. It kind of has this kind of squiggly inside and then a circular outside. Um, the mitochondria produce ATP. That's the energy currency of the cell. Now, if you go to go back way back in evolution, back in the day, we probably were an animal cell that engulfed a bacterial cell, which was the mitochondrial cell, and said, hey, that's a good source of energy. We want it inside. And so one thing a lot of people don't know is that mitochondria have their own DNA. So when you have an embryo when you're born, okay, you actually have three sets of genetic material you inherit. You have half the chromosomes from mom, half the chromosomes from dad, and then you get a full set of mitochondrial DNA from the mother. And of course, this is how uh you could, in theory, have an embryo that has three parents. Wow. Wow. So mitochondria have been around for a very long time. And in the past 10 years or so, there's been a growing awareness of hmm, these actually probably do more than we thought they did. And one example of that is MOTC. That's one of the peptides on the list for rediscussion, potential reclassification next month. MOT C is a peptide produced by your mitochondria that goes into the nucleus of your cells and affect how your DNA is turned into proteins. What's novel about this is that the nucleus was always considered the command center of the cell. The nucleus is a center, whatever the nucleus says and does goes. The idea that you have something outside of the nucleus, like the mitochondria, that has its own genome producing its own peptides. On its own agenda. He's lobbying in our nucleus. That's right. That's exactly right. That's exactly right. Um, MOT C is a great product. Um, it's great for energy, that's great for metabolism. It's uh an anabolic, it's a non-hormonal anabolic, which is uh sort of a unique property. Uh, it's great for energy, smooth energy. And I'd say in general, the mitochondrial peptides are great for energy, physical and mental, but they don't incur a debt. And I think that's a really important distinction relative to, let's say, caffeine. Too much caffeine, now I feel jittery. Too much testosterone, now I feel on edge. It's a very smooth energy that just kind of dials things up, but doesn't uh make you feel irritable on edge, gives you some anxiety afterwards, which being in New York City, those are great options.

SPEAKER_02 12:24

Yeah. So you're saying next month the FDA is about to review all of these things, and how does that affect? I mean, is the pharmaceutical industry shaking in their boots? Because I'm sure they don't really care about it anymore. Or are they salivating at the mouth? Like, I don't understand what the You're asking a very good question.

SPEAKER_00 12:40

Yeah. And I think one important detail, and this will apply to peptide and peptide science, and I think some of the gaps in peptide science, which I think is, you know, one of the challenges to the emergence of all these peptides, is that any compound that is naturally occurring in the body, MOTC is an example, cannot be patented. It exists. It has existed. That means you didn't come up with it. Now, what

Gray Market Access And FDA Flux

SPEAKER_00 13:05

Big Pharma could do is say, the MOTC is nice, but we're gonna create a new unique compound by going in there and changing one thing, and then we can patent it. It doesn't even have to be a useful thing they change. It usually would be something designed to enhance the efficacy or the half-life of the compound. So all that is to say is naturally occurring compounds cannot be patented. And if compounds can't be patented, it would be highly unlikely that some entity will then fund millions to billions of dollars to fund the clinical trials to demonstrate its efficacy. Wow. So that's one of the big challenges with peptides. If they occur naturally, they can't be patented. So no one's gonna do the research. Of course, it would be great if someone did the research so we could actually test these things out, but the way the pharmaceutical landscape is set up in the country seems highly unlikely. Interesting.

SPEAKER_01 13:54

And the and the the weight loss drugs, the Ozempic, trizepatizer, and all of those, those are obviously have uh something that they could be patented. Of course. Of course, of course. And I again, I always, I mean, just to get out of the out of the science of it all, I always believe, you know, as it's written, that God sends the cure before the disease. So the disease of obesity is here, and here's your cure. So like people are fighting it and like coming so strongly out against it. People who never tried it, you know, and then um and they're amazing. What can I say? They're amazing. They they I I've I've done two different ones with you, and I'm currently on the trizeptide, and it just helps. When you're traveling, when you're just when you're not in a in a in the for me, when you're not in a straight rhythm of eating and having food and and just and exercising, and you're flying, and 6 a.m. You have to be on a plane and wake up at four. These things help. It helps you stay conscious when you're stabilize. Yeah, but it just helps you, you know, like yesterday I had a show. We walked in, and where the people were having a show, they had little snacks for them. So unconsciously, I just grabbed a handful of jelly beans, which is like 250 calories, easily, and that's when I knew. Oh, I forgot. That's right. I f I was off on my on my dosing of mitrose. And so I was like, oh, that's right. And so this morning I did it. Um, it helps you stay conscious of your of your eating. Like, I don't need to finish all of that, I don't need to order another one. I'll just go to sleep now without eating. That, but then, but then there's people who are like, it's the worst thing in the world for you. I feel nauseous, I feel sick, I need a bathroom, I go crazy.

Mitochondrial Peptides And MOTS-c

SPEAKER_01 15:50

And then we were just talking about that. Just try taking a little less.

SPEAKER_02 15:54

Just just yeah, how do you find your dosing? When you're guiding people through trying these different things, how do you check in with them?

SPEAKER_00 16:04

Yeah, I I think you know, the kind of three main variables here are which GLP1, what's the dose, and what's the frequency. So you have a bunch of different variables, but really it comes down to what are you actually trying to achieve and what are the baseline characteristics of the person taking it. So, for instance, you know, uh the the jelly bean feedback can definitely be helpful, right? You're like, oh, okay, obviously I I haven't taken this in a in a while. And I think one thing you're kind of talking about here is ultimately getting control back.

SPEAKER_01 16:34

Yeah.

SPEAKER_00 16:35

Right? Yeah. It's not feeling driven or affected by your environment and sort of uh caloric options, but you're sort of in the driver's seat. And I think for a lot of people who have felt like they're not in the driver's seat for quite some time and feel a little bit out of control, uh, can be extremely helpful. What's that food noise? The food noise, that's exactly right. And I think what's food noise mean they call it food noise. I I think only someone who has experienced food noise can really know what food noise is, but it's sort of the underlying chatter that's just driving of like, what am I having next? What am I eating next? What am I gonna drink? Yes. Oh, there's cookies over there. I'm in the lounge, they have things over here.

SPEAKER_02 17:10

Right. There's there's a internal assessments that are happening. Yeah, you're like, if I eat now, what will I have for dinner? And it's just like that's just being Jewish.

SPEAKER_01 17:20

That's not called baseline. That's just being Jewish. We're having breakfast now, what are we doing for lunch? When's lunch? Okay, afterwards, dinner.

SPEAKER_02 17:28

Well, there's some people who are just not motivated by food, and there's some people who it's all they can think about.

SPEAKER_00 17:32

And I think the GLP ones like turn the volume down on the and I think for someone who has never experienced food noise, it's it's hard for them to understand or empathize with individuals who do suffer from that, and uh, and it's hard for them to to know what that benefit is because they haven't experienced that issue. Right. Um, now food noise specifically, I will tell you, you know, newer is not always better, right? There's a strong tendency, people want the newest product in the pipeline. There was semaglutide, now they want the tersebatide, now there's redotrutides, they always want the new new. But the truth is that newer products are not always better, and that younger generations of products might actually be superior depending on the person and the goal. And food noise is actually a very good example of this. Food noise is most responsive to semaglutide. Alcohol reduction, most responsive to semaglutide. However, if at baseline you have some gastrointestinal issues, you're someone who gets motion sickness, you know, get nauseous easily, you might have some acid reflux, you have constipation at baseline, semaglutide you're gonna be very unhappy with because it'll exacerbate all those issues. In those cases, we might escalate to terasepatite. It's a bit more balanced from a gastrointestinal profile and therefore way less likely to cause unwanted effects, makes it more tolerable. However, I've definitely seen some people who maybe they have trouble tolerating semaglutide, they switch to trosepatide, they can drink through the trzebatite. The semaglutide they can't. So there are a lot of nuances between these products. Really depends on the person, on the goal.

SPEAKER_02 19:04

Yeah. And when you say the alcohol reduction part, is because it turns off the receptors of your brain that make that enjoyable.

SPEAKER_00 19:12

So all pleasurable pathways in the brain converge on the same area. It's called the nucleus accumbens. This is where all the dopamine gets released. There are lots of different pathways and behaviors that stimulate and activate that part of the brain. For some people, it could be food, other people could be alcohol, other people could be sex, gambling, nicotine, fill, fill in the consumption of choice. Yeah. Right? So typically, for, or I'll should say, for some individuals, when the nucleus accumbens gets activated and you have this dopamine being released, it creates this positive feedback loop where you continue seeking out that reward to continue this sort of dopamine release. You continue eating, you continue drinking, you continue, again, fill in the blank. So one of the ways in which GLP ones function is that they decrease this positive feedback to therefore decrease your desire to continue that behavior.

SPEAKER_02 20:05

And doctors are prescribing GLP1s for alcohol uh to inhibit people's alcohol intake.

SPEAKER_00 20:11

I mean, I I I have been for for quite some time.

SPEAKER_02 20:13

Yeah. I saw a commercial on TV for a drug that was specifically marketed towards alcohol reducing your alcohol intake.

SPEAKER_00 20:21

I think you're probably thinking of naltrexone.

SPEAKER_02 20:23

Yeah. It was it was about it was it wasn't about weight loss or anything. It was just like, I no longer feel that or I can't one drink is enough for me. Like correct. It was very much that.

SPEAKER_00 20:33

And and look, maybe you have someone who, you know, overall uh intake from a caloric standpoint is is not an an issue. Or or maybe it's the the opposite. Maybe they struggle to get enough calories in. So giving those individuals GLP ones would not be good to reduce their alcohol. Alcoholics don't eat. I forgot about that. So again, alcoholics don't really eat? In extreme versions, you know, you're really prioritizing alcohol over everything else. So it's uh very possible and even probable you get you know vitamin mineral deficiencies, things like this, so it can really become problematic. So, but but again, it all comes down to the person, the and what they're trying to achieve.

SPEAKER_02 21:05

So the would you say there's different pillars of peptides that are let's say weight loss is here, longevity, skin, hair stuff. What are the drawers that you're what drawers can we open?

SPEAKER_00 21:19

You're you're asking about taxonomy and nomenclature, which I No one said those words. You just said what I'm thinking.

SPEAKER_01 21:25

I have no idea what he's a scientist. Taxonomy is what you have what you do to your dog after he dies, so you can keep it in the living room. Is that taxidermy? That's taxidermy. You don't have a dog, right? No. Oh not anymore.

SPEAKER_00 21:38

Put a big bear in the I I think that um uh the the typical person would would think about these from a sort of a goal driven approach. Yeah, right. So um I I would agree. I I think they're probably gonna be thinking in in those buckets in terms of like what are the outcomes?

SPEAKER_02 21:52

So, what are the ones that are are for skin and hair and things like that?

SPEAKER_00 21:56

Sure. So um one peptide that you'll see. Anywhere and everywhere now is GHK copper. Okay. Okay. GHK copper is three amino acids, so it's a very short peptide plus a copper activating ion. This combination activates fibroblasts. Those are the cells in your skin which are responsible for collagen production. Okay. So GHA copper has emerged as an adjunct to help kind of stimulate collagen production. So if we're doing microneedling in the office, it can actually be used as a glide. So the mechanical trauma is activating

Dosing Nuance Food Noise Alcohol

SPEAKER_00 22:30

repair. And then you're also then giving the signal to activate the fibroblast to make collagen. That's kind of one of the goals of doing microneedling. GHA copper can also be applied topically. And I will say GHK copper is one of these uh interesting peptides insofar as the FDA has different classifications depending on how you administer it. Topical, go for it. Injectable, they're not so thrilled with, at least uh not right now, but again, that could change next month. Okay. Uh in terms of other things for skin, uh BPC157, thymus and beta, KPV. Which is the one that makes you tan? Is that a that would be melanitan. How do you feel about that? You know, um so there are different forms of melanitan. There's melanitan 1 and melanitan 2. Melanitan 1 was the only version that was ever approved. It was never actually, I'm not sure if it was approved in the US, it was for sure approved in in Europe. Um this was actually approved for people who have um uh disproportionate responses to UV. So it was a compound they could take to increase melanin production in their skin so that when they would go in the sun, they wouldn't have these very severe UV responses.

SPEAKER_02 23:40

Like people who burn easily?

SPEAKER_00 23:42

Yes, and there are other conditions which I won't get. Basically allergic to the sun. But yes, essentially. So uh that's what you know, melanotan one was originally developed for. Melanitan two came out later. Um, it's an even stronger version of melanitan one, so the sort of timeline for increased melanin production uh is is more expedited. It's also uh way more likely to uh give you a little bit of nausea, reduce appetite, and make you horny relative to melanitan one. Increased libido. Right. Summary, a summary point. Well, when I'm 10, I'm feeling good. Feeling good. Yeah. Yeah. But I I think the real, or at least I should say one of the challenges there is oh, I mean, I'll say there are there are a few. The more practical challenge there are the secret frecklers. They're very unhappy with melanotan products. Because it will bring those freckles out. So if someone's already done laser and other things like that to reduce the freckles on face or body, whatever it is, they're probably not gonna be very happy if they start melanotan products. Um, the of course, the the feared complication with melanotan is that if someone has an undiagnosed melanoma, they're like, hey, like take a bunch of melanitan. Wow. Not not a good idea. So no, look, I think you know, skin checks should be part of kind of annual exams, especially kind of depending on you know, skin tone, things like this. Um at a baseline, checking not only for melanoma, also looking for squamous cell, basal cell, other forms of of skin cancer. So um I I I would say I think that's a spicier pep uh that I I I think that um, you know just one I've heard of. Yes, yes.

SPEAKER_02 25:10

Um what about the NAD stuff? What is go I that's something I feel like I don't have a good comprehension of it? Then you'll have to ask me back for uh NAD plus. NAD Plus, they are doing like IV drips with it, and I don't know.

SPEAKER_00 25:26

We'll we'll have to have a dedicated session about mitochondria because uh NAD plus is you know in in in the realm of mitochondria and in and technically is not a peptide. So it's not a peptide. Yeah, we'll we'll strike that from the peptide conversation, but you can make a note about the mitochondria and NAD plus. Uh it's also all very interesting.

SPEAKER_01 25:43

Okay. Okay, so anybody listening to this now who's just all of a sudden, poor thing, just listen to us thinking, oh, it's just me Moting Leo again, and then we brought we brought the mitochondria on. Um where can they start? How can they how can people who are interested in this like where where's the bet where's the uh safest place to get these these peptides and and to figure out d d doses and and which ones would work for them?

SPEAKER_00 26:13

Yeah, no, it's I think it's a great question. And I think one uh one general point of feedback I would give before giving an answer here is I think there's a general tendency for people to um have peptide-driven regimens. When really the regimens should be goal-driven.

unknown 26:30

Okay.

SPEAKER_00 26:30

You should be identifying what your goal is and then working backwards to understand what are the tools to achieve that goal. What are the low friction options that are very easy to do? What are the kind of higher friction, more complex options? I think that coming in with I need this peptide is not good is not the right order of operation. So, of course, having a consultation, really understanding where you're at, what your goals are, um, performing a baseline set of labs to see if there are any metabolic imbalances

Skin Hair Peptides And Melanotan Risks

SPEAKER_00 26:55

that should be corrected first before you think about peptides. Um I will say, you know, one limitation with many peptides is there aren't commercially available tests through lab corp requests to measure your natural levels of these peptides. It would certainly help kind of inform some of the conversation, I think, uh, with people who are considering certain peptides or if they could be helpful to them. Uh, but there aren't tests available for for many of these, or at least not yet. So I would say start with a consultation with someone who is well versed in medicine generally, also knowledgeable of peptides to see based on your goals if any of those would be applicable.

unknown 27:26

Okay.

SPEAKER_00 27:26

And of course, through a, you know, a compounding pharmacy.

SPEAKER_01 27:29

I like the goal thing. I like the goal, what's your goal? And then nothing.

SPEAKER_00 27:32

No, you work backwards. He's doing that. I want to try what he's doing. Yes. It's very, you know, if you go into you know, the sort of T-Nation bodybuilder forums, it's very product driven. It's product obsessed. Yeah. What are the products? What am I taking? What's the schedule? Here's the calendar.

SPEAKER_02 27:46

It's really crazy with the crazy. I'm in there. I listened to it.

SPEAKER_01 27:49

You should I mean, listen. I'm sure you're seeing it too. I think I mentioned it on another podcast. You know, whenever anybody sees anybody that's built and in shape, yeah. Go, what's your secret? Totally. What peptides are you taking? It's not one secret. But we were to Shabbat dinner, and there's this one guy who just like built, and just we no one was expecting this guy to be at this dinner, and he's a brother of a guy who's not built at all. And he's just sitting there with muscles, and everybody just started going, What is your secret? And he knew this, and he just told them creatine. And they all went, Oh, yeah. He he obviously it's he wakes up every day, jogs, and runs and lifts and that. But he just might it might inject to a thing or two just to get them off his back creatine. Yeah, and they're all right away on their phones ordering creatine. I did the gummy card.

SPEAKER_02 28:33

Yeah, yeah. By the way, I've started, I've I've been good about my creatine journey. Yeah, we've what do you what do you think? How many grams are you taking? I'm up to 10. Oh, wow. A scoop. Yeah. No, I've been doing two scoops. I was like, that's a double scoop. Double scoop. I did one scoop for a few weeks, and then because you can get the bloat, you can get the creatine bloat.

SPEAKER_00 28:50

I I will say I have trouble tolerating creatine. My weight will go up 10 pounds. Really?

SPEAKER_02 28:53

No, my weight did go up a little bit, but I feel good at the gym. Like I I feel like it's been a few months now, and I upped the dose to 10. And um, but speaking of creatine, I mean, there's people who maybe bodybuilding is not their goal, but there's all sorts of benefits to creatine monohydrate in the brain, no?

SPEAKER_00 29:14

Sure.

SPEAKER_02 29:15

Um, you know, there's research coming out about that, or we've always known that.

SPEAKER_00 29:18

There is, but we're also gonna diverge a little bit from the peptide conversation if you want to go down. We can do whatever listen, I'm I'm the science steward over here, so you let me know. I'll steer the ship. We can divert. We can divert whatever you can go into talking about anything you want. You know, uh no, I think creatine definitely has uh come into the sort of forefront of the of the public generally. Um, you know, five grams is a typical dose in terms of athletic performance, kind of body composition support. Once you kind of get into the 10, 15 gram range, you're talking about sort of neurosupport. Um, and I think I expect more and more data to kind of become available uh about creatine. I think that uh for most people, um, you know, there definitely is a potential upside to capture. Um, but I will say that the most common reason why creatine is discontinued is due to excessive food retention. And so that can manifest as uh abdominal fullness, loss of abdominal definition, rounding of the face, um, just sort of a distributed water definite uh, you know, retention. So um so yeah, it's it's in order for that to happen, you need to be scooping a lot of that. You have to take a lot. And and and look, I I think that you know, creatine is of the class of everyone's looking for the one thing.

SPEAKER_01 30:27

That that's what this that's what of course telling everybody.

SPEAKER_00 30:30

That's it. If I just do this, then it just, you know, the the reality is the body is extremely complex. Yeah. There's so many different things.

SPEAKER_02 30:38

Everyone's body is different.

SPEAKER_00 30:39

Everyone's body is different. We're at the very kind of infancy of really understanding the the complexity of how all these systems interact, and it's just a matter of time before we realize it's way more complicated than we originally thought.

SPEAKER_01 30:50

Right, right. And again, the goals are are are look for me, it's when we're in heavy travel, when I'm on a plane day after day after day, and she comes by with that little cookie tray. Like, here, would you like a little snack, those biscotti things? What are those things? Oh, I'll take three or four. Right. So if I'm if if I'm in my if I'm in a good place with my trosepatite, I'll just say no, thank you, like that. And it gives you the option to judge people that do take. That's right. Yeah, and which is a good which is a fun thing to do. Um, and then like, oh, when they just come out, would you would you are you are you will you be joining us for lunch? I'm like, well, where are you pulling lunch out of that toilet? Some toilet with cabinets? Um, yeah, you can like no, I'm good, thank you. Uh, and control yourself in the in the Delta Lounge and just just like oh, I'm good with just a coffee

Start With Goals Not A Product List

SPEAKER_01 31:40

right now, thank you. That's that's the goal for me to have the control that that control for other people it's something else.

SPEAKER_02 31:47

But that's just like to thank our sponsors. Um in case they are a little hungry, maybe they want a hot dog.

SPEAKER_01 31:53

If you now now you have to eat and enjoy yourself, and there's no better way to enjoy eating than through AH provisions, glot kosher, delicious food. Um, which I do, I do indulge. I do indulge in when I do have it. And um, and they are first of all, hot dog wise, we are in the summer. This is hot dog season. They are the most delicious and freshest and and uh uh healthiest if as far as a hot dog can go, and glot kosher uh hot dogs in the world. And it there's a 30% promo code when you use Modi as the promo code, 30% off of your first order, and everything's on kosher dogs.net. And uh thank you guys always for sending pictures whenever you see them in Costco or wherever you see them sending it to us, and like, hey, this is Modi's sponsor. Um, thank you, Seth and Matt. And of course, Whites and Luxembourg, the law from the not only does well, they do good. Super philanthropic, Arthur Luxembourg, friend of the podcast, and Randy, his wife, who listens to it to tell him what we're talking about. Thank you guys for being a part of uh our uh our podcast. All right, um, Dr.

SPEAKER_02 33:07

K, where can um people find you?

SPEAKER_00 33:10

Where can um probably through website is probably a good good uh starting point. Which is drk.nyc. That's right. W dot doctor spelled out do c t o r letter k dot nyc. Amazing.

SPEAKER_01 33:25

Yeah. We are uh we are I'm over eleven years with you. Yes, I'm over eleven years with you. You probably are nine years with him. Yeah, yeah, and we feel good keeping us healthy and looking good.

SPEAKER_00 33:41

Yeah, my pleasure, a pleasure to do it, and um happy to come back when you know to answer any other medical questions.

SPEAKER_02 33:49

We should uh yeah, we're we're if you have health and wellness questions, um let's do a fun episode. Submit your questions, let's get into it. Red light therapy, NAD, whatever it is that's floating around in your brain, and we'll put together some educational funds.

SPEAKER_01 34:07

I can I already know I already know what what we're getting here. We're gonna be

Sponsors Where To Find Dr K

SPEAKER_01 34:10

getting I tried this and that, and I was not sure. Well, my aunt had cancer, so then I bought her this thing and it worked. And then it was a crystal. She spold it to me in a speech. How much does he charge? Does insurance pay for him? That's what we'll be getting, and we're looking forward to you. We love all of your contacts, and then of course, we're gonna be getting what happened to Leo's hair. Oh, that's gonna be a thing, too. Stay tuned, stay tuned. He just he he lost all coy. He just did to to to do all of that quaffing. Um, I think it looks good. I think it's amazing. It looks great. Summer ready. Summer ready. Speaking of which, everybody again, thank you, everybody that came to the Radio City Music Hall shows, and we are working on the new hour. I've been at the comedy cellar, and I'm gonna be on the road. I'm gonna be in Nashville, I'm gonna be in Sacramento, I'm gonna be in uh Raleigh, North Carolina, and also in Portland, Oregon. All of this is happening in July. Get your tickets. If your friends are in that area, let them know so you can be the friend that brings the friends to the comedy show. Everything's available on ModiLive.com. We also have shows in London. Atlantic City. Atlantic City. Uh it's not sold out yet. Um, it's about to sell out. It's about to sell out.

SPEAKER_02 35:29

Atlantic City. Um, and two shows in London, Montreal, Ottawa. Yeah. Um, and if you live in the LA area, we have a wait list option for a December show that details are coming soon, but you can be the first to know if you go to that. And also, if you live near Huntington, New York in Long Island, there is also an option there to join the wait list for that show, which is also coming soon. So um, all sorts of voices. But everything's on ModiLive.com.com.

SPEAKER_01 36:01

Thank you all very, very much. And uh, we will hear from you, see you, and uh laugh with you. Bye. Bye.